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KMID : 0882420100780030375
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Korean Journal of Medicine
2010 Volume.78 No. 3 p.375 ~ p.380
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A case of adult nesidioblastosis mimicking an insulinoma and autoimmune hypoglycemia
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Lee Ye-Nna
Kim Min-Joo
Kim Tae-Hyuk
Lim Jung-Ah
Kim Su-Jung
Kim Hae-Ryoung
Choi Sung-Hee
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Abstract
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Hyperinsulinemic hypoglycemia in the absence of exogenous insulin use is caused by disorders such as insulinoma, diffuse β-cell hyperplasia/nesidioblastosis, and autoimmune hypoglycemia. Nesidioblastosis is a rare cause of hypoglycemia in adults, accounting for 0.5~7.0% of organic hyperinsulinemia cases. Although pancreatic resection is considered the best treatment modality for curing nesidioblastosis, there is no consensus regarding the indications for and extent of the surgery due to its high risk and complication rate. A 75-year-old woman presented with an altered mental state, a mass suspected of being an insulinoma, and insulin receptor antibodies. The patient underwent surgery because of recurrent life-threatening hypoglycemia. Postoperative pathology of her pancreas revealed nesidioblastosis.
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KEYWORD
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Nesidioblastosis, Insulinoma, Insulin receptor antibody, Hyperinsulinemia, Hypoglycemia
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